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Our Mini-stim IVF™ Results
Our pregnancy rates with Mini-stim IVF are included as part of IVF in the SART/CDC data reporting for IVF programs. This is likely because Mini-stim IVF (or Mini-IVF) is not recognized as a different procedure than IVF and is done by only a few programs in the United States. However, mixing this data decreases the value of it for understanding how either IVM or Mini-stim IVF (or IVM) is done in this program.
Infertility Solutions’ Pregnancy Results using Mini-stim IVF for 2010-2011
As for IVF, success rates very much depend on age. However, since only a few eggs are retrieved each cycle with Mini-stim IVF, results appear to depend more strongly on the underlying cause of infertility. Mini-stim IVF works best when there is a male factor or a tubal problem. It has a lower success rate for egg related problems. Never the less, anyone may use Mini-stim IVF.
Women under age 35 (normal ovarian reserve)
Ongoing or delivered pregnancy rate per transfer- 6/14 = 42.9%
Ongoing or delivered pregnancy rate per patient- 6/8 = 75%
Clinical pregnancy rate per transfer- 7/14 = 50%
Biochemical pregnancy rate per transfer- 8/14 = 57.1%
There were no cycle cancellations after starting medications.
Comments. The cycle cancellation rate is lower than conventional IVF and markedly lower than natural cycle IVF. Note that this data applies to young women who are good candidates for conventional IVF. The pregnancy rate is similar to conventional IVF, but for self pay patients, the cost per pregnancy is about one third.
Women aged 40 and above
Ongoing or delivered pregnancy rate per transfer- 3/14 = 21.4%
Ongoing or delivered pregnancy rate per patient- 3/11 = 27.3%
Clinical pregnancy rate per transfer- 4/14 = 28.6%
There were three cycles that were cancelled before transfer.
Comments: The patients aged from 40 to 45. The AMH in some patients was not detectable. All three pregnant patients were age 42. With conventional IVF, these patients would have received high does of gonadotropins. The self-pay cost per cycle for these patients was about one fourth of conventional IVF. The pregnancy rate appears similar to or higher than that for conventional IVF for this age group of patients.
Women aged 35 through 39 (normal ovarian reserve)
Ongoing or delivered pregnancy rate per transfer- 2/6 = 33.3%
One cycle was cancelled before transfer.
Women under age 40 (abnormal ovarian reserve)
With prior failed IVF cycles
Ongoing or delivered pregnancy rate per transfer- 0/6 = 0%
Biochemical pregnancy rate per transfer- 1/6 = 16.7%
One cycle was cancelled before transfer.
Without prior IVF cycles
Ongoing or delivered pregnancy rate per transfer- 1/8= 12.5%
Biochemical pregnancy rate per transfer- 3/8 = 37.5%
One cycle was cancelled before transfer.
Comments. Patients were determined to have abnormal ovarian reserve based on antral follicle counts (AFCs), AMH levels, or poor response in a prior IVF cycle. Our cycle numbers are too low to draw any solid conclusions. Conventional IVF may be a better option for some of these patients.